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KMID : 0362220110380030321
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Journal of The Korean Research Society for Dental Materials
2011 Volume.38 No. 3 p.321 ~ p.326
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Enhanced Strength of the Tissue Engineering Scaffold
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Kim Sung-Min
Kim Kwang-Man
Lee Yong-Keun
You Chang-Kook
Lee Kang-Sik
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Abstract
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Calcium phosphate such as Hydroxyapatite (HA) and beta tri-calcium phosphate (β-TCP), due to its excellent biocompatibility and bioactivity, is widely used in the clinic of orthopedic as well as dental applic ations. The HA h as g ood biologic al p roperties like n on-immunogenicity, n on-inflammatory behavior, high osteoconductivity and osteoinductivity. The β-TCP shows the good biocompatibility and biodegradability. Especially, calcium phosphate scaffolds have interconnected pores that provide a favorable environment for bone i ngrowth, o sseointegration a nd b lood s upply. T he c alc ium phosphate sc affold, however, h as brittle property and low strength. The purpose of this study was to investigate the effects of a kind and each amount of binder and fabrication methods for high compressive strength of calcium phosphate scaffold. At HA scaffold, the maximum compressive strength was performed when combined binder of 3 wt% of polyvinyl alcohol and 1 wt% of methyl cellulose was selected. The β-TCP scaffold fabricated by novel template- casting has high compressive strength than sponge method.
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KEYWORD
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Calcium phosphate, Compressive strength, Hydroxyapatite, Scaffold, Tri-calcium phosphate
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